The most unique feature and why this game might stay digital is that there is a timer aspect to it. Other than resources, cards take a short period of time to "activate". I find the game not too tough to pick up and from the forum postings at TouchArcade, it seems that you might need to spend some more money buying packs (via in-app purchase) if you want to build a stronger deck fast or to complete your card set. I personally might go the route of slowly building points via single campaign and multiplayer. The interface to edit your deck is nicely designed and not a hassle unlike the Marvel Trading Card Game, this is a really important aspect which Yugioh has excel at.
Assassin's Creed console players who have sign up for Ubisoft's UPlay account can login from this game too and it looks like there might be some link between this iPad game to the Assassin's Creed universe. Overall, the graphics look beautiful and the sound is just like the console, although I suspect I'll be playing mute when outside. It shows that a card game can be played out well on an iPad and it is a shame that big names in trading card games have not arrived on a tablet first. Wizards of the Coast and Konami, are you looking at this game?
iTunes App Store link: